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KMID : 0545119970070010056
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Journal of Microbiology and Biotechnology
1997 Volume.7 No. 1 p.56 ~ p.61
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Immunsuppressive Characteristics of Oligomycin Derivatives Produced by Streptomyces lydicus MCY-524
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Lee, Sang Yong
Han, Sang Bae/Kim, Hang Sub/Kim, Young Ho/Kim, Hwan Mook/Kim, Chang Jin/Hong, Soon Duck
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Abstract
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A strain producing immunosuppressive substances was isolated from a soil in Cheju island. By morphological, cultural, and physiological studies, the strain was identified as Streptomyces lydicus MCY524. Cultured broth was purified by silica gel, sephadex LH-20 and preparative HPLC and gave two immunosuppressive compounds, MCH-22 and MCH-32. They dramatically suppressed the B cell activation with lipopolysaccharide, T cell activation by mixed lymphocyte response, and primary T-dependent antibody response at a final concentration of 1 ㎍/㎖. They also markedly suppressed the proliferation of lymphocytes induced by lipopolysaccharide, pokeweed mitogen, and concanavaline A at the same concentration. Their suppressive activities, which were comparable to those of cyclosporin A, suggested that they were potent and broad immunotoxic agents on the immune functions of murine lymphocytes.
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